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Symptoms: Mild cases of diphenhydramine overdose are mainly characterized by dry mouth, headache, nausea, tachycardia (fast heart rate), and urinary retention. In children, the clinical features include hallucinations, dilated pupils, fever, ataxia, and convulsions. Cardiorespiratory depression and coma may subsequently develop, with death occurring between 2 to 18 hours. Adults usually develop drowsiness first, then convulsion, and coma at a later stage. Signs and symptoms of phenylpropanolamine overdose include tachycardia, arrhythmia (irregular heart beat), high blood pressure, excitation, enlargement of the pupils. Cases of heart attack, stroke, intracranial hemorrhage/cerebral hemorrhage (bleeding from a ruptured blood vessel in the brain), seizures, and death have also been reported.
Treatment: If the patient have taken more than the recommended dosage, consult a doctor or contact a poison control center right away.
